Advances in genetics and genomics have led to the development of GM crops during the early nineties. Agricultural biotechnology is perhaps the single most significant technology that got wide acceptance after the green revolution. Agricultural biotechnology has obvious advantages in terms of higher yields, improved nutritive value, reduced pesticide consumption, enhanced stress tolerance of the crop etc. Though protocols are available for assessing the safety aspects of GM crops, the society at large is concerned about the safe use of such varieties. Cultivation of GM crops increased tremendously from 1996 onwards. Now GM crops are cultivated in a total area of 189.8 million hectares in 26 different countries. In terms of global area under biotech crops, the US occupies first position with an area of 75 mha, followed by Brazil (50.2 mha), Argentina (23.6 mha), Canada (13.1 mha) and India (11.4 mha). The major GM crops now cultivated globally include soybean, maize, cotton and canola. Still more GM crops such as rice and banana are in the pipeline under different stages of field testing in many countries. The only commercially grown GM crop in India is Bt cotton. India became the largest producer and exporter of cotton by the adoption of Bt technology and has the world’s fifth largest area with a single GM crop. Though several countries, particularly in Europe restrict GM crop cultivation, import of the same as food/feed is permitted. It is expected that countries such as China might come up with more GM crops and will become a major player in agricultural biotechnology in near future.